Periodic mass loss episodes due to an oscillation mode with variable amplitude in the hot supergiant HD50064

We aim to interpret the photometric and spectroscopic variability of the luminous blue variable supergiant HD\,50064 ($V=8.21$).CoRoT space photometry and follow-up high-resolution spectroscopy, with a time base of 137\,d and 169\,d, respectively, was gathered, analysed and interpreted using standard time series analysis and light curve modelling methods as well as spectral line diagnostics.The space photometry reveals one period of 37\,d, which undergoes a sudden amplitude change with a factor 1.6. The pulsation period is confirmed in the spectroscopy, which additionally reveals metal line radial velocity values differing by $\sim 30\,$km\,s$^{-1}$ depending on the spectral line and on the epoch. We estimate \teff$\sim$13\,500\,K, \logg$\sim$1.5 from the equivalent width of Si lines. The Balmer lines reveal that the star undergoes episodes of changing mass loss on a time scale similar to the changes in the photometric and spectroscopic variability, with an average value of $\log\dot{\rm M}\simeq-5$ (in M$_\odot$\,yr$^{-1}$). We tentatively interpret the 37\,d period as due to a strange mode oscillation.Comment: 4 pages, accepted for publication in Astronomy & Astrophysics Letter

An Exact Algorithm for Side-Chain Placement in Protein Design

Computational protein design aims at constructing novel or improved functions on the structure of a given protein backbone and has important applications in the pharmaceutical and biotechnical industry. The underlying combinatorial side-chain placement problem consists of choosing a side-chain placement for each residue position such that the resulting overall energy is minimum. The choice of the side-chain then also determines the amino acid for this position. Many algorithms for this NP-hard problem have been proposed in the context of homology modeling, which, however, reach their limits when faced with large protein design instances. In this paper, we propose a new exact method for the side-chain placement problem that works well even for large instance sizes as they appear in protein design. Our main contribution is a dedicated branch-and-bound algorithm that combines tight upper and lower bounds resulting from a novel Lagrangian relaxation approach for side-chain placement. Our experimental results show that our method outperforms alternative state-of-the art exact approaches and makes it possible to optimally solve large protein design instances routinely

Archives lacustres de l'évolution du climat et des activités humaines récentes dans les Pyrénées ariégeoises au cours de l'Holocène (étang majeur, vallée du Haut-Vicdessos, Pyrénées, France)

International audienceDans le cadre de l'Observatoire Hommes Milieux Haut-Vicdessos, des archives lacustres sont utilisées pour distin-guer les impacts de l'Homme ou du climat dans les Pyrénées (Ariège, 42°N). Associée à la cartographie acoustique de l'Étang Majeur, les analyses des sols et des sédi-ments lacustres mettent en évidence une sédimentation Tardiglaciaire riche en ti-tane, qui contraste avec une sédimentation Holocène de type dy résultant de l'érosion diffuse des tourbes présentes en amont du lac. L'enregistrement indique des périodes plus humides, datées en 1200, 1950, 3400 et 4550 cal BP et associées aux apports d'un canyon drainant les zones d'altitude. Depuis 1907, le niveau d'eau du lac est ré-gulé par deux barrages hydroélectriques. Il en résulte un marnage de 10 m affec-tant jusqu'à 37 % du bassin. Ceci a pour conséquences de remobiliser le matériel issu des berges, et d'augmenter la produc-tivité algaire et les taux d'accumulation